IFNA1

Chr 9p21.3

interferon alpha 1

Aliases:: IFNA@, IFL, IFN, IFN-ALPHA, IFNA13
MANE:: ENST00000276927.3

OMIM: 147660 ↗NCBI: 3439 ↗Ensembl ↗

Annotations refreshed 1 month ago.

Predicted protein structure

AlphaFold predicted structure

IFNA1 · P0DY56

Mean pLDDT

Not published

AlphaFold has not published a prediction for this sequence. This is common for very long proteins.

Confidence breakdown

Check AlphaFold DB

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

COVID-19 research
Unknown

Disease associations (Open Targets)

renal cell carcinoma
0.39
systemic lupus erythematosus
0.15
dermatomyositis
0.13
infection
0.12
neoplasm
0.12
COVID-19
0.12
hepatocellular carcinoma
0.12
cancer
0.12
major depressive disorder
0.12
depressive disorder
0.11

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Interferon alpha-1

Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase