IFNE

Chr 9p21.3

interferon epsilon

Aliases:: IFNE1
MANE:: ENST00000448696.4

OMIM: 615223 ↗NCBI: 338376 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

IFNE · Q86WN2

v62025-08-01

Predicted Aligned Error matrix for IFNE — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

81.6/ 100

Confident

208 residues

Confidence breakdown

Very high(≥ 90)39%
Confident(70–90)42%
Low(50–70)14%
Very low(< 50)4%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

COVID-19 research
Unknown

Disease associations (Open Targets)

hypothyroidism
0.24
thyroid gland disorder
0.18
crush injury
0.18
liver disorder
0.18
myxedema
0.16
Hypercholesterolemia
0.16
ovarian dysfunction
0.16
response to antihypertensive drug
0.16
nutritional deficiency disease
0.15
autoimmune thyroid disease
0.15

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Interferon epsilon

Type I interferon required for maintaining basal levels of IFN-regulated genes, including 2'-5'-oligoadenylate synthetase, IRF7 and ISG15, in the female reproductive tract. Directly mediates protection against viral and bacterial genital infections (By similarity)