IFNGR1

Chr 6q23.3

interferon gamma receptor 1

Aliases:: CD119
MANE:: ENST00000367739.9

OMIM: 107470 ↗NCBI: 3459 ↗Ensembl ↗

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Predicted protein structure

AlphaFold predicted structure

IFNGR1 · P15260

v62025-08-01

Predicted Aligned Error matrix for IFNGR1 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

66.0/ 100

Low

489 residues

Confidence breakdown

Very high(≥ 90)36%
Confident(70–90)10%
Low(50–70)13%
Very low(< 50)42%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

COVID-19 research
BOTH monoallelic and biallelic (but BIALLELIC mutations cause a more SEVERE disease form), autosomal or pseudoautosomal
Primary immunodeficiency or monogenic inflammatory bowel disease
BOTH monoallelic and biallelic (but BIALLELIC mutations cause a more SEVERE disease form), autosomal or pseudoautosomal

Disease associations (Open Targets)

disseminated atypical mycobacterial infection
0.54
chronic granulomatous disease
0.53
idiopathic pulmonary fibrosis
0.49
mycobacterial infectious disease
0.46
osteopetrosis
0.44
Oral ulcer
0.43
neoplasm
0.41
cystic fibrosis
0.40
Friedreich ataxia
0.37
Hepatic fibrosis
0.37

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Interferon gamma receptor 1

Receptor subunit for interferon gamma/INFG that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation (PubMed:20015550). Associates with transmembrane accessory factor IFNGR2 to form a functional receptor (PubMed:10986460, PubMed:2971451, PubMed:7615558, PubMed:7617032, PubMed:7673114). Upon ligand binding, the intracellular domain of IFNGR1 opens out to allow association of downstream signaling components JAK1 and JAK2. In turn, activated JAK1 phosphorylates IFNGR1 to form a docking site for STAT1. Subsequent phosphorylation of STAT1 leads to dimerization, translocation to the nucleus, and stimulation of target gene transcription (PubMed:28883123). STAT3 can also be activated in a similar manner although activation seems weaker. IFNGR1 intracellular domain phosphorylation also provides a docking site for SOCS1 that regulates the JAK-STAT pathway by competing with STAT1 binding to IFNGR1 (By similarity)