IFNGR2

Chr 21q22.11

interferon gamma receptor 2

Aliases:: AF-1
MANE:: ENST00000290219.11

OMIM: 147569 ↗NCBI: 3460 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

IFNGR2 · P38484

v62025-08-01

Predicted Aligned Error matrix for IFNGR2 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

83.8/ 100

Confident

337 residues

Confidence breakdown

Very high(≥ 90)62%
Confident(70–90)11%
Low(50–70)19%
Very low(< 50)8%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

COVID-19 research
BOTH monoallelic and biallelic, autosomal or pseudoautosomal
Primary immunodeficiency or monogenic inflammatory bowel disease
BOTH monoallelic and biallelic, autosomal or pseudoautosomal

Disease associations (Open Targets)

immunodeficiency 28
0.76
Mendelian susceptibility to mycobacterial diseases due to complete IFNgammaR2 deficiency
0.56
chronic granulomatous disease
0.53
idiopathic pulmonary fibrosis
0.49
rheumatoid arthritis
0.48
Crohn disease
0.48
osteopetrosis
0.44
inflammatory bowel disease
0.42
neoplasm
0.40
cystic fibrosis
0.39

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Interferon gamma receptor 2

Associates with IFNGR1 to form a receptor for the cytokine interferon gamma (IFNG) (PubMed:7615558, PubMed:7673114, PubMed:8124716). Ligand binding stimulates activation of the JAK/STAT signaling pathway (PubMed:15356148, PubMed:7673114, PubMed:8124716). Required for signal transduction in contrast to other receptor subunit responsible for ligand binding (PubMed:7673114)