IGF2

Chr 11p15.5

insulin like growth factor 2

Aliases:: FLJ44734, IGF-II
MANE:: ENST00000416167.7

OMIM: 147470 ↗NCBI: 3481 ↗Ensembl ↗

Annotations refreshed 1 month ago.

Predicted protein structure

AlphaFold predicted structure

IGF2 · P01344

v62025-08-01

Predicted Aligned Error matrix for IGF2 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

59.0/ 100

Low

180 residues

Confidence breakdown

Very high(≥ 90)1%
Confident(70–90)16%
Low(50–70)55%
Very low(< 50)28%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

DDG2P
MONOALLELIC, autosomal or pseudoautosomal, maternally imprinted (paternal allele expressed)
Fetal anomalies
MONOALLELIC, autosomal or pseudoautosomal, maternally imprinted (paternal allele expressed)
Monogenic short stature
MONOALLELIC, autosomal or pseudoautosomal, maternally imprinted (paternal allele expressed)
Silver Russell syndrome
MONOALLELIC, autosomal or pseudoautosomal, paternally imprinted (maternal allele expressed)
Beckwith-Wiedemann syndrome (BWS) and other congenital overgrowth disorders
MONOALLELIC, autosomal or pseudoautosomal, maternally imprinted (paternal allele expressed)
Childhood solid tumours
Intellectual disability
Other - please specify in evaluation comments
IUGR and IGF abnormalities
MONOALLELIC, autosomal or pseudoautosomal, maternally imprinted (paternal allele expressed)

Disease associations (Open Targets)

Silver-Russell syndrome due to a point mutation
0.72
Silver-Russell syndrome
0.68
Beckwith-Wiedemann syndrome
0.59
maturity-onset diabetes of the young type 10
0.47
diabetes mellitus, permanent neonatal 4
0.45
hyperproinsulinemia
0.45
hereditary disease
0.41
isolated hemihyperplasia
0.38
Hemihypertrophy
0.38
diabetes mellitus
0.37

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Insulin-like growth factor 2

The insulin-like growth factors possess growth-promoting activity (By similarity). Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development. IGF2 is influenced by placental lactogen. Also involved in tissue differentiation. In adults, involved in glucose metabolism in adipose tissue, skeletal muscle and liver (Probable). Acts as a ligand for integrin which is required for IGF2 signaling (PubMed:28873464). Positively regulates myogenic transcription factor MYOD1 function by facilitating the recruitment of transcriptional coactivators, thereby controlling muscle terminal differentiation (By similarity). Inhibits myoblast differentiation and modulates metabolism via increasing the mitochondrial respiration rate (By similarity)