AlphaFold predicted structure
IGFALS · P35858
Mean pLDDT
90.6/ 100
Very high
605 residues
Confidence breakdown
- Very high(≥ 90)86%
- Confident(70–90)5%
- Low(50–70)2%
- Very low(< 50)7%
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AlphaFold (Jumper et al., 2021) · CC BY 4.0
IGFALS
Chr 16p13.3insulin like growth factor binding protein acid labile subunit
- Aliases:
- ALS
- MANE:
- ENST00000215539.4
Annotations refreshed 9 hours ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
IUGR and IGF abnormalities
BIALLELIC, autosomal or pseudoautosomalMonogenic short stature
BIALLELIC, autosomal or pseudoautosomalPaediatric disorders - additional genes
BIALLELIC, autosomal or pseudoautosomal
Disease associations (Open Targets)
Reduced insulin like growth factor binding protein acid labile subunit concentration
0.77short stature due to primary acid-labile subunit deficiency
0.71Abnormality of the skeletal system
0.46Delayed puberty
0.37Short stature
0.37short stature due to GHSR deficiency
0.37hereditary disease
0.19hypertensive disorder
0.11Blount disease
0.08familial digital arthropathy-brachydactyly
0.08
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Insulin-like growth factor-binding protein complex acid labile subunit
Involved in protein-protein interactions that result in protein complexes, receptor-ligand binding or cell adhesion