IGFBP7

Chr 4q12

insulin like growth factor binding protein 7

Aliases:: MAC25, IGFBP-7, PSF, FSTL2
MANE:: ENST00000295666.6

OMIM: 602867 ↗NCBI: 3490 ↗Ensembl ↗

Annotations refreshed 1 month ago.

Predicted protein structure

AlphaFold predicted structure

IGFBP7 · Q16270

v62025-08-01

Predicted Aligned Error matrix for IGFBP7 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

84.4/ 100

Confident

282 residues

Confidence breakdown

Very high(≥ 90)66%
Confident(70–90)14%
Low(50–70)9%
Very low(< 50)12%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

DDG2P
BIALLELIC, autosomal or pseudoautosomal
Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

familial retinal arterial macroaneurysm
0.61
alcohol drinking
0.32
atrial fibrillation
0.31
schizophrenia
0.30
protozoa infectious disease
0.29
degeneration of macula and posterior pole
0.28
refractive error
0.28
hyperemesis gravidarum
0.27
diabetes mellitus
0.27
head and neck cancer
0.27

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Insulin-like growth factor-binding protein 7

Binds IGF1 and IGF2 with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion. Acts as a ligand for CD93 to play a role in angiogenesis (PubMed:38218180)