IGSF10

Chr 3q25.1

immunoglobulin superfamily member 10

Aliases:: FLJ25972, CMF608
MANE:: ENST00000282466.4

OMIM: 617351 ↗NCBI: 285313 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

IGSF10 · Q6WRI0

v62025-08-01

Predicted Aligned Error matrix for IGSF10 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

58.4/ 100

Low

2,623 residues

Confidence breakdown

Very high(≥ 90)3%
Confident(70–90)45%
Low(50–70)12%
Very low(< 50)40%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Hypogonadotropic hypogonadism (GMS)
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

temporomandibular joint disorder
0.30
stricture or kinking of ureter
0.25
neuroendocrine neoplasm
0.23
urolithiasis
0.21
alcohol drinking
0.21
placental retention
0.19
Delayed puberty
0.19
hypogonadotropic hypogonadism
0.19
primary ovarian failure
0.17
hereditary disease
0.16

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Immunoglobulin superfamily member 10

Involved in the control of early migration of neurons expressing gonadotropin-releasing hormone (GNRH neurons) (By similarity). May be involved in the maintenance of osteochondroprogenitor cells pool (By similarity)