IKZF2

Chr 2q34

IKAROS family zinc finger 2

Aliases:: Helios
MANE:: ENST00000434687.6

OMIM: 606234 ↗NCBI: 22807 ↗Ensembl ↗

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Predicted protein structure

AlphaFold predicted structure

IKZF2 · Q9UKS7

v62025-08-01

Predicted Aligned Error matrix for IKZF2 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

52.4/ 100

Low

526 residues

Confidence breakdown

Very high(≥ 90)0%
Confident(70–90)33%
Low(50–70)13%
Very low(< 50)53%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Primary immunodeficiency or monogenic inflammatory bowel disease
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Fetal anomalies
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
DDG2P
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Disease associations (Open Targets)

ICHAD syndrome
0.55
hypothyroidism
0.45
prostate carcinoma
0.43
immunodysregulation with variable immunodeficiency and autoimmunity
0.42
systemic lupus erythematosus
0.41
allergic rhinitis
0.40
smoking initiation
0.38
Abnormality of the skeletal system
0.38
neurodegenerative disease
0.38
glaucoma
0.32

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Zinc finger protein Helios

Transcription factor, which stabilizes the noninflammatory phenotype of regulatory T cells (Tregs) (By similarity). May possibly act via STAT5-mediated signaling (By similarity). Binds IL2 promoter and represses its transcription, possibly by epigenetic silencing, inducing deacetylation of core histones in the IL2 promoter (PubMed:37316189). In Tregs, required for FOXP3 recruitment to the IL2 promoter (By similarity). Required for outer hair cells maturation and, consequently, for hearing (By similarity)