IKZF3

Chr 17q12-q21.1

IKAROS family zinc finger 3

Aliases:: Aiolos
MANE:: ENST00000346872.8

OMIM: 606221 ↗NCBI: 22806 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

IKZF3 · Q9UKT9

v62025-08-01

Predicted Aligned Error matrix for IKZF3 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

47.9/ 100

Very low

509 residues

Confidence breakdown

Very high(≥ 90)1%
Confident(70–90)19%
Low(50–70)23%
Very low(< 50)57%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Primary immunodeficiency or monogenic inflammatory bowel disease
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Disease associations (Open Targets)

immunodeficiency 84
0.63
B-cell chronic lymphocytic leukemia
0.44
neurodegenerative disease
0.43
prostate adenocarcinoma
0.37
cutaneous melanoma
0.37
lymphoid neoplasm
0.37
carcinoma of liver and intrahepatic biliary tract
0.37
skin squamous cell carcinoma
0.37
breast ductal adenocarcinoma
0.37
HER2 positive breast carcinoma
0.37

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Zinc finger protein Aiolos

Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2-dependent manner