AlphaFold predicted structure
IL10 · P22301
Mean pLDDT
87.9/ 100
Confident
178 residues
Confidence breakdown
- Very high(≥ 90)78%
- Confident(70–90)6%
- Low(50–70)2%
- Very low(< 50)14%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
IL10
Chr 1q32.1interleukin 10
- Aliases:
- CSIF, TGIF, IL10A, IL-10
- MANE:
- ENST00000423557.1
Annotations refreshed 1 month ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
COVID-19 research
BIALLELIC, autosomal or pseudoautosomalGastrointestinal epithelial barrier disorders
BIALLELIC, autosomal or pseudoautosomalPrimary immunodeficiency or monogenic inflammatory bowel disease
BIALLELIC, autosomal or pseudoautosomalInfantile enterocolitis & monogenic inflammatory bowel disease
BIALLELIC, autosomal or pseudoautosomalFamilial Meniere Disease
Sudden death in young people
Unknown
Disease associations (Open Targets)
Crohn disease
0.61inflammatory bowel disease
0.59IL10-related early-onset inflammatory bowel disease
0.57ulcerative colitis
0.55type 1 diabetes mellitus
0.53systemic lupus erythematosus
0.52rheumatoid arthritis
0.48Behcet disease
0.43ulcer disease
0.43ulcerative proctosigmoiditis
0.43
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Interleukin-10
Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3 (PubMed:16982608). In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators (PubMed:18025162). Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines including granulocyte-macrophage colony-stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G-CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF (PubMed:11564774, PubMed:1940799, PubMed:7512027). Also interferes with antigen presentation by reducing the expression of MHC-class II and co-stimulatory molecules, thereby inhibiting their ability to induce T cell activation (PubMed:8144879). In addition, controls the inflammatory response of macrophages by reprogramming essential metabolic pathways including mTOR signaling (By similarity)
Diseases associated with IL10
Curated MONDO disease pages that list IL10 among their top associated genes.