IL10RA

Chr 11q23.3

interleukin 10 receptor subunit alpha

Aliases:: HIL-10R, CDW210A, CD210a, CD210
MANE:: ENST00000227752.8

OMIM: 146933 ↗NCBI: 3587 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

IL10RA · Q13651

v62025-08-01

Predicted Aligned Error matrix for IL10RA — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

62.0/ 100

Low

578 residues

Confidence breakdown

Very high(≥ 90)33%
Confident(70–90)9%
Low(50–70)5%
Very low(< 50)54%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

COVID-19 research
BIALLELIC, autosomal or pseudoautosomal
Gastrointestinal epithelial barrier disorders
BIALLELIC, autosomal or pseudoautosomal
Infantile enterocolitis & monogenic inflammatory bowel disease
BIALLELIC, autosomal or pseudoautosomal
Primary immunodeficiency or monogenic inflammatory bowel disease
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

Autosomal recessive early-onset inflammatory bowel disease
0.81
IL10-related early-onset inflammatory bowel disease
0.55
inflammatory bowel disease
0.39
ulcerative colitis
0.37
cervical carcinoma
0.27
pancreatic ductal adenocarcinoma
0.26
pancreatic adenocarcinoma
0.26
malignant pancreatic neoplasm
0.26
eye injury
0.22
hereditary disease
0.19

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Interleukin-10 receptor subunit alpha

Cell surface receptor for the cytokine IL10 that participates in IL10-mediated anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Upon binding to IL10, induces a conformational change in IL10RB, allowing IL10RB to bind IL10 as well (PubMed:16982608). In turn, the heterotetrameric assembly complex, composed of two subunits of IL10RA and IL10RB, activates the kinases JAK1 and TYK2 that are constitutively associated with IL10RA and IL10RB respectively (PubMed:12133952). These kinases then phosphorylate specific tyrosine residues in the intracellular domain in IL10RA leading to the recruitment and subsequent phosphorylation of STAT3. Once phosphorylated, STAT3 homodimerizes, translocates to the nucleus and activates the expression of anti-inflammatory genes. In addition, IL10RA-mediated activation of STAT3 inhibits starvation-induced autophagy (PubMed:26962683)