interleukin 10 receptor subunit beta
Annotations refreshed 9 hours ago.
Diagnostic Grade (Green)
COVID-19 research
BIALLELIC, autosomal or pseudoautosomalGastrointestinal epithelial barrier disorders
BIALLELIC, autosomal or pseudoautosomalInfantile enterocolitis & monogenic inflammatory bowel disease
BIALLELIC, autosomal or pseudoautosomalPrimary immunodeficiency or monogenic inflammatory bowel disease
BIALLELIC, autosomal or pseudoautosomalinflammatory bowel disease 25
Autosomal recessive early-onset inflammatory bowel disease
IL10-related early-onset inflammatory bowel disease
COVID-19
inflammatory bowel disease
ulcerative colitis
chronic hepatitis C virus infection
hepatitis C virus infection
pancreatic ductal adenocarcinoma
pancreatic adenocarcinoma
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Interleukin-10 receptor subunit beta
Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IFNL1. The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state
Curated MONDO disease pages that list IL10RB among their top associated genes.
IL10RB · Q08334
Mean pLDDT
82.1/ 100
Confident
325 residues
Confidence breakdown
AlphaFold (Jumper et al., 2021) · CC BY 4.0
