IL11RA

Chr 9p13.3

interleukin 11 receptor subunit alpha

MANE:: ENST00000441545.7

OMIM: 600939 ↗NCBI: 3590 ↗Ensembl ↗

Annotations refreshed 10 hours ago.

Predicted protein structure

AlphaFold predicted structure

IL11RA · Q14626

v62025-08-01

Predicted Aligned Error matrix for IL11RA — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

81.6/ 100

Confident

422 residues

Confidence breakdown

Very high(≥ 90)60%
Confident(70–90)13%
Low(50–70)9%
Very low(< 50)17%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

DDG2P
BIALLELIC, autosomal or pseudoautosomal
Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal
Rare syndromic craniosynostosis or isolated multisuture synostosis
BIALLELIC, autosomal or pseudoautosomal
Skeletal dysplasia
BIALLELIC, autosomal or pseudoautosomal
Intellectual disability
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

craniosynostosis and dental anomalies
0.77
Thrombocytopenia
0.49
craniosynostosis
0.46
craniosynostosis syndrome, autosomal recessive
0.46
neoplasm
0.40
autoimmune disorder of central nervous system
0.23
acute leukemia
0.18
protozoa infectious disease
0.18
von Willebrand disease (hereditary or acquired)
0.10
glioblastoma
0.09

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Interleukin-11 receptor subunit alpha

Receptor for interleukin-11 (IL11). The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells (Probable). Essential for the normal development of craniofacial bones and teeth. Restricts suture fusion and tooth number