AlphaFold predicted structure
IL12B · P29460
Mean pLDDT
91.1/ 100
Very high
328 residues
Confidence breakdown
- Very high(≥ 90)81%
- Confident(70–90)10%
- Low(50–70)2%
- Very low(< 50)6%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
IL12B
Chr 5q33.3interleukin 12B
- Aliases:
- CLMF, IL-12B, NKSF, CLMF2
- MANE:
- ENST00000231228.3
Annotations refreshed 1 month ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
COVID-19 research
BIALLELIC, autosomal or pseudoautosomalPrimary immunodeficiency or monogenic inflammatory bowel disease
BIALLELIC, autosomal or pseudoautosomalGastrointestinal epithelial barrier disorders
Disease associations (Open Targets)
psoriasis
0.80Crohn disease
0.74psoriasis vulgaris
0.74psoriatic arthritis
0.74ulcerative colitis
0.73inflammatory bowel disease
0.60immune system disorder
0.55skin disorder
0.54seborrheic dermatitis
0.52erythematosquamous dermatosis
0.49
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Interleukin-12 subunit beta
Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC
Diseases associated with IL12B
Curated MONDO disease pages that list IL12B among their top associated genes.