IL12RB2

Chr 1p31.3

interleukin 12 receptor subunit beta 2

MANE:: ENST00000674203.2

OMIM: 601642 ↗NCBI: 3595 ↗Ensembl ↗

Annotations refreshed 1 month ago.

Predicted protein structure

AlphaFold predicted structure

IL12RB2 · Q99665

v62025-08-01

Predicted Aligned Error matrix for IL12RB2 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

72.9/ 100

Confident

862 residues

Confidence breakdown

Very high(≥ 90)38%
Confident(70–90)30%
Low(50–70)9%
Very low(< 50)23%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

COVID-19 research
BIALLELIC, autosomal or pseudoautosomal
Primary immunodeficiency or monogenic inflammatory bowel disease
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

primary biliary cholangitis
0.46
rheumatoid arthritis
0.46
hypothyroidism
0.45
systemic lupus erythematosus
0.43
Crohn disease
0.42
systemic sclerosis
0.42
biliary liver cirrhosis
0.40
Behcet disease
0.37
Mendelian susceptibility to mycobacterial diseases
0.37
neurodegenerative disease
0.35

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Interleukin-12 receptor subunit beta-2

Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as NK cells. Induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production