IL17RD

Chr 3p14.3

interleukin 17 receptor D

Aliases:: SEF, IL17RLM, FLJ35755, IL-17RD
MANE:: ENST00000296318.12

OMIM: 606807 ↗NCBI: 54756 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

IL17RD · Q8NFM7

v62025-08-01

Predicted Aligned Error matrix for IL17RD — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

68.3/ 100

Low

739 residues

Confidence breakdown

Very high(≥ 90)34%
Confident(70–90)23%
Low(50–70)7%
Very low(< 50)37%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Hypogonadotropic hypogonadism
BIALLELIC, autosomal or pseudoautosomal
Hypogonadotropic hypogonadism (GMS)
BIALLELIC, autosomal or pseudoautosomal
Fetal anomalies
Unknown

Disease associations (Open Targets)

Kallmann syndrome
0.75
hypogonadotropic hypogonadism 18 with or without anosmia
0.55
Abnormality of the skeletal system
0.38
Delayed puberty
0.36
neurodegenerative disease
0.33
chronic obstructive pulmonary disease
0.30
Cerebral arteriovenous malformation
0.30
asthma
0.30
placenta praevia
0.14
hypogonadotropic hypogonadism
0.12

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Interleukin-17 receptor D

Feedback inhibitor of fibroblast growth factor mediated Ras-MAPK signaling and ERK activation (PubMed:12807873, PubMed:12958313). Regulates the nuclear ERK signaling pathway by spatially blocking nuclear translocation of activated ERK without inhibiting cytoplasmic phosphorylation of ERK (PubMed:15239952). Mediates JNK activation and may be involved in apoptosis (By similarity). May inhibit FGF-induced FGFR1 tyrosine phosphorylation (By similarity). Might have a role in the early stages of fate specification of GnRH-secreting neurons (By similarity). Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity)