IL18

Chr 11q23.1

interleukin 18

Aliases:: IGIF, IL1F4, IL-1g, IL-18
MANE:: ENST00000280357.12

OMIM: 600953 ↗NCBI: 3606 ↗Ensembl ↗

Annotations refreshed 1 month ago.

Predicted protein structure

AlphaFold predicted structure

IL18 · Q14116

v62025-08-01

Predicted Aligned Error matrix for IL18 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

89.0/ 100

Confident

193 residues

Confidence breakdown

Very high(≥ 90)68%
Confident(70–90)19%
Low(50–70)11%
Very low(< 50)1%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

COVID-19 research
Unknown
Familial Meniere Disease
Primary immunodeficiency or monogenic inflammatory bowel disease

Disease associations (Open Targets)

hemophagocytic syndrome
0.28
adult-onset Still disease
0.14
type 2 diabetes mellitus
0.13
smoking initiation
0.13
systemic lupus erythematosus
0.13
rheumatoid arthritis
0.12
chronic obstructive pulmonary disease
0.12
neoplasm
0.12
acute kidney injury
0.12
infection
0.12

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Interleukin-18

Pro-inflammatory cytokine primarily involved in epithelial barrier repair, polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses (PubMed:10653850). Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators (PubMed:14528293, PubMed:25500532, PubMed:37993714). Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells (PubMed:10653850). Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore (PubMed:33883744)