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IL18BP

Chr 11q13.4

interleukin 18 binding protein

Aliases:
IL18BPa
MANE:
ENST00000393703.9
OMIM: 604113 ↗NCBI: 10068 ↗Ensembl ↗

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Predicted protein structure

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

  • COVID-19 research

    MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

  • Primary immunodeficiency or monogenic inflammatory bowel disease

    BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

  • neoplasm

    0.09

  • idiopathic pulmonary fibrosis

    0.08

  • Eczematoid dermatitis

    0.07

  • gastric adenocarcinoma

    0.07

  • asthma

    0.07

  • rheumatoid arthritis

    0.07

  • X-linked lymphoproliferative disease

    0.07

  • autoimmune thrombocytopenic purpura

    0.07

  • metabolic dysfunction-associated steatohepatitis

    0.06

  • immunodeficiency 128

    0.06

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Interleukin-18-binding protein

Isoform A binds to IL-18 and inhibits its activity. Functions as an inhibitor of the early TH1 cytokine response

Data sources: HGNC (CC BY 4.0), AlphaFold (CC BY 4.0, Jumper et al. Nature 2021), Genomics England PanelApp (CC BY 4.0), ClinGen, Open Targets (CC0), UniProt.

Not for sole clinical decision-making. Always verify against primary sources.