IL1R1

Chr 2q11.2-q12.1

interleukin 1 receptor type 1

Aliases:: D2S1473, CD121A
MANE:: ENST00000410023.6

OMIM: 147810 ↗NCBI: 3554 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

IL1R1 · P14778

v62025-08-01

Predicted Aligned Error matrix for IL1R1 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

83.9/ 100

Confident

569 residues

Confidence breakdown

Very high(≥ 90)51%
Confident(70–90)33%
Low(50–70)11%
Very low(< 50)6%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Primary immunodeficiency or monogenic inflammatory bowel disease
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Familial Meniere Disease

Disease associations (Open Targets)

rheumatoid arthritis
0.59
Ascending aortic dissection
0.45
asthma
0.41
inflammatory bowel disease
0.41
COVID-19
0.40
CINCA syndrome
0.38
immune system disorder
0.37
neurodegenerative disease
0.35
gout
0.34
chronic recurrent multifocal osteomyelitis 3
0.34

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Interleukin-1 receptor type 1

Receptor for IL1A, IL1B and IL1RN (PubMed:2950091, PubMed:37315560). After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. Involved in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (PubMed:10653850)