AlphaFold predicted structure
IL1RN · P18510
Mean pLDDT
87.1/ 100
Confident
177 residues
Confidence breakdown
- Very high(≥ 90)78%
- Confident(70–90)3%
- Low(50–70)4%
- Very low(< 50)15%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
IL1RN
Chr 2q14.1interleukin 1 receptor antagonist
- Aliases:
- IL1RA, ICIL-1RA, IL1F3, IRAP, IL-1RN
- MANE:
- ENST00000409930.4
Annotations refreshed 1 month ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
Autoinflammatory disorders
BIALLELIC, autosomal or pseudoautosomalCOVID-19 research
BIALLELIC, autosomal or pseudoautosomalPeriodic fever syndromes
BIALLELIC, autosomal or pseudoautosomalPrimary immunodeficiency or monogenic inflammatory bowel disease
BIALLELIC, autosomal or pseudoautosomalRare genetic inflammatory skin disorders
BIALLELIC, autosomal or pseudoautosomalSkeletal dysplasia
BIALLELIC, autosomal or pseudoautosomalFetal anomalies
BIALLELIC, autosomal or pseudoautosomalDiabetes with additional phenotypes suggestive of a monogenic aetiology
Disease associations (Open Targets)
sterile multifocal osteomyelitis with periostitis and pustulosis
0.77gout
0.56abdominal aortic aneurysm
0.44diabetic retinopathy
0.37ischemic stroke
0.37coronary artery disorder
0.37venous thromboembolism
0.36autoinflammatory syndrome
0.34hypothyroidism
0.30hypertrophic cardiomyopathy
0.27
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Interleukin-1 receptor antagonist protein
Anti-inflammatory antagonist of interleukin-1 family of proinflammatory cytokines such as interleukin-1beta/IL1B and interleukin-1alpha/IL1A. Protects from immune dysregulation and uncontrolled systemic inflammation triggered by IL1 for a range of innate stimulatory agents such as pathogens