IL21R

Predicted protein structure

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

• COVID-19 research

  BIALLELIC, autosomal or pseudoautosomal

• Primary immunodeficiency or monogenic inflammatory bowel disease

  BIALLELIC, autosomal or pseudoautosomal

• Severe multi-system atopic disease with high IgE

Disease associations (Open Targets)

• Cryptosporidiosis - chronic cholangitis - liver disease

  0.74

• cryptosporidiosis-chronic cholangitis-liver disease syndrome

  0.73

• asthma

  0.53

• primary biliary cholangitis

  0.44

• respiratory system disorder

  0.43

• hypothyroidism

  0.43

• allergic disease

  0.38

• Abnormal thrombosis

  0.37

• immunodeficiency disease

  0.37

• severe combined immunodeficiency

  0.37

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)