AlphaFold predicted structure
IL23R · Q5VWK5
Mean pLDDT
68.2/ 100
Low
629 residues
Confidence breakdown
- Very high(≥ 90)42%
- Confident(70–90)11%
- Low(50–70)10%
- Very low(< 50)37%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
IL23R
Chr 1p31.3interleukin 23 receptor
- Aliases:
- IL-23R
- MANE:
- ENST00000347310.10
Annotations refreshed 1 month ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
COVID-19 research
BIALLELIC, autosomal or pseudoautosomalPrimary immunodeficiency or monogenic inflammatory bowel disease
BIALLELIC, autosomal or pseudoautosomalGastrointestinal epithelial barrier disorders
Disease associations (Open Targets)
inflammatory bowel disease
0.66psoriasis
0.56Crohn disease
0.56ulcerative colitis
0.56enteritis
0.51ankylosing spondylitis
0.51sarcoidosis
0.49colitis
0.47psoriasis vulgaris
0.47autoimmune disease
0.45
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Interleukin-23 receptor
Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis
Diseases associated with IL23R
Curated MONDO disease pages that list IL23R among their top associated genes.