IL27RA

Chr 19p13.12

interleukin 27 receptor subunit alpha

Aliases:: WSX-1, TCCR, CRL1, WSX1, zcytor1
MANE:: ENST00000263379.4

OMIM: 605350 ↗NCBI: 9466 ↗Ensembl ↗

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Predicted protein structure

AlphaFold predicted structure

IL27RA · Q6UWB1

v62025-08-01

Predicted Aligned Error matrix for IL27RA — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

78.9/ 100

Confident

636 residues

Confidence breakdown

Very high(≥ 90)40%
Confident(70–90)35%
Low(50–70)12%
Very low(< 50)13%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Primary immunodeficiency or monogenic inflammatory bowel disease
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

Epstein-Barr virus infection
0.19
neoplasm
0.11
infection
0.11
hepatocellular carcinoma
0.10
atherosclerosis
0.08
breast carcinoma
0.08
breast cancer
0.08
triple-A syndrome
0.08
Miyoshi myopathy
0.08
benign prostatic hyperplasia
0.07

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Interleukin-27 receptor subunit alpha

Signal-transducing subunit for an heterodimeric cytokine composed of IL27/p28 and a soluble receptor EBI3 (PubMed:14764690, PubMed:36930708). Heterodimerizes with IL6ST/GP130 to mediate signal transduction in response to the heterodimeric cytokine IL27/p28-EBI3. This signaling system acts through STAT3 and STAT1 (PubMed:14764690, PubMed:38509369). Also acts as a signaling receptor as part of the humanin receptor complex; binding of MT-RNR2/humanin (HN) activates the intracellular JAK-STAT3 signaling pathway leading to neuroprotection (PubMed:19386761). Involved in the regulation of Th1-type immune responses (By similarity). Also appears to be involved in innate defense mechanisms (PubMed:14764690)