IL2RA

Predicted protein structure

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

• COVID-19 research

  BIALLELIC, autosomal or pseudoautosomal

• Gastrointestinal epithelial barrier disorders

  BIALLELIC, autosomal or pseudoautosomal

• Infantile enterocolitis & monogenic inflammatory bowel disease

  BIALLELIC, autosomal or pseudoautosomal

• Neonatal diabetes

  BIALLELIC, autosomal or pseudoautosomal

• Primary immunodeficiency or monogenic inflammatory bowel disease

  BIALLELIC, autosomal or pseudoautosomal

• Diabetes with additional phenotypes suggestive of a monogenic aetiology

  BIALLELIC, autosomal or pseudoautosomal

• Familial diabetes

  BIALLELIC, autosomal or pseudoautosomal

• Familial Meniere Disease

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Disease associations (Open Targets)

• immunodeficiency due to CD25 deficiency

  0.79

• multiple sclerosis

  0.63

• type 1 diabetes mellitus

  0.57

• primary cutaneous T-cell non-Hodgkin lymphoma

  0.56

• kidney transplant

  0.53

• rheumatoid arthritis

  0.53

• renal cell carcinoma

  0.52

• neoplasm

  0.51

• hypothyroidism

  0.49

• metastatic melanoma

  0.48

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Diseases associated with IL2RA

Curated MONDO disease pages that list IL2RA among their top associated genes.

• multiple sclerosisRare
• type 1 diabetes mellitusRare