IL2RB

Chr 22q12.3

interleukin 2 receptor subunit beta

Aliases:: CD122
MANE:: ENST00000216223.10

OMIM: 146710 ↗NCBI: 3560 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

IL2RB · P14784

v62025-08-01

Predicted Aligned Error matrix for IL2RB — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

64.6/ 100

Low

551 residues

Confidence breakdown

Very high(≥ 90)33%
Confident(70–90)9%
Low(50–70)19%
Very low(< 50)39%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

COVID-19 research
BIALLELIC, autosomal or pseudoautosomal
Primary immunodeficiency or monogenic inflammatory bowel disease
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

Immunodeficiency syndrome with autoimmunity
0.67
primary cutaneous T-cell non-Hodgkin lymphoma
0.54
multiple sclerosis
0.53
kidney transplant
0.53
renal cell carcinoma
0.52
neoplasm
0.50
neurodegenerative disease
0.49
metastatic melanoma
0.48
immune system disorder
0.46
asthma
0.46

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Interleukin-2 receptor subunit beta

Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15 (PubMed:15123770, PubMed:31040185)