IL3

Chr 5q31.1

interleukin 3

Aliases:: IL-3, MULTI-CSF, MCGF, MGC79398, MGC79399
MANE:: ENST00000296870.3

OMIM: 147740 ↗NCBI: 3562 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

IL3 · P08700

v62025-08-01

Predicted Aligned Error matrix for IL3 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

83.3/ 100

Confident

152 residues

Confidence breakdown

Very high(≥ 90)59%
Confident(70–90)14%
Low(50–70)26%
Very low(< 50)1%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

COVID-19 research
Unknown

Disease associations (Open Targets)

atopic eczema
0.34
asthma
0.17
psoriasis
0.15
myocardial infarction
0.14
neoplasm
0.10
Sepsis
0.10
dermatitis
0.09
systemic lupus erythematosus
0.09
Alzheimer disease
0.09
inflammatory bowel disease
0.09

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Interleukin-3

Cytokine secreted predominantly by activated T-lymphocytes as well as mast cells and osteoblastic cells that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells (PubMed:2556442). Also stimulates mature basophils, eosinophils, and monocytes to become functionally activated (PubMed:10779277, PubMed:32889153). In addition, plays an important role in neural cell proliferation and survival (PubMed:23226269). Participates as well in bone homeostasis and inhibits osteoclast differentiation by preventing NF-kappa-B nuclear translocation and activation (PubMed:12816992). Mechanistically, exerts its biological effects through a receptor composed of IL3RA subunit and a signal transducing subunit IL3RB (PubMed:29374162). Receptor stimulation results in the rapid activation of JAK2 kinase activity leading to STAT5-mediated transcriptional program (By similarity). Alternatively, contributes to cell survival under oxidative stress in non-hematopoietic systems by activating pathways mediated by PI3K/AKT and ERK (PubMed:27862234)