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IL31RA

Chr 5q11.2

interleukin 31 receptor A

Aliases:
CRL3, GLM-R, CRL, Glmr, IL-31RA
MANE:
ENST00000652347.2
OMIM: 609510 ↗NCBI: 133396 ↗Ensembl ↗

Annotations refreshed 1 month ago.

Predicted protein structure

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

  • Pigmentary skin disorders

    MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

  • COVID-19 research

    MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

  • Periodic fever syndromes

    MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

  • Primary immunodeficiency or monogenic inflammatory bowel disease

    MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Disease associations (Open Targets)

  • familial primary localized cutaneous amyloidosis

    0.54

  • atopic eczema

    0.54

  • prurigo nodularis

    0.49

  • prurigo

    0.46

  • Pruritus

    0.43

  • Eczematoid dermatitis

    0.37

  • placental retention

    0.28

  • rheumatic disorder

    0.16

  • palindromic rheumatism

    0.16

  • systemic sclerosis

    0.11

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Interleukin-31 receptor subunit alpha

Functions as a membrane-bound signal-transducing subunit of the IL31 receptor complex (heterodimer composed of OSMR and IL31RA) which binds IL31 (PubMed:15184896, PubMed:15194700, PubMed:15627637). Functionally, IL31 signaling via OSMR/IL31RA is particularly important in skin immunity (PubMed:15184896). Mechanistically, ligand binding induces heterodimerization with OSMR, activating JAK1 and JAK2 (and to a lesser extent TYK2) associated with the intracellular domains of IL31RA and OSMR (PubMed:15194700, PubMed:15627637). These kinases phosphorylate tyrosine residues on IL31RA and OSMR, creating docking sites for STAT1, STAT3, and STAT5B, which are then phosphorylated and activated (Probable) (PubMed:11877449, PubMed:15194700, PubMed:15627637). In addition, the IL31 receptor complex activates the MAPK pathway (MAPK3/ERK1-MAPK1/ERK2) via recruitment of the adapter protein SHC1 (PubMed:15194700, PubMed:15627637). Mediates IL31-induced itch, probably in a manner dependent on cation channels TRPA1 and TRPV1 (By similarity). Positively regulates numbers and cycling status of immature subsets of myeloid progenitor cells in bone marrow in vivo and enhances myeloid progenitor cell survival in vitro (By similarity)

Diseases associated with IL31RA

Curated MONDO disease pages that list IL31RA among their top associated genes.

Data sources: HGNC (CC BY 4.0), AlphaFold (CC BY 4.0, Jumper et al. Nature 2021), Genomics England PanelApp (CC BY 4.0), ClinGen, Open Targets (CC0), UniProt.

Not for sole clinical decision-making. Always verify against primary sources.