IL36RN

Predicted protein structure

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

• Autoinflammatory disorders

  BIALLELIC, autosomal or pseudoautosomal

• COVID-19 research

  BIALLELIC, autosomal or pseudoautosomal

• Generalised pustular psoriasis

  BOTH monoallelic and biallelic (but BIALLELIC mutations cause a more SEVERE disease form), autosomal or pseudoautosomal

• Periodic fever syndromes

  BIALLELIC, autosomal or pseudoautosomal

• Primary immunodeficiency or monogenic inflammatory bowel disease

  BIALLELIC, autosomal or pseudoautosomal

• Rare genetic inflammatory skin disorders

  BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

• psoriasis 14, pustular

  0.80

• generalized pustular psoriasis

  0.64

• autoinflammatory syndrome

  0.45

• palmoplantar pustulosis

  0.38

• post term pregnancy

  0.30

• quality of life cycle

  0.25

• coronary artery disorder

  0.22

• ischemic stroke

  0.22

• abdominal aortic aneurysm

  0.20

• hereditary disease

  0.19

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)