AlphaFold predicted structure
IL6 · P05231
Mean pLDDT
85.3/ 100
Confident
212 residues
Confidence breakdown
- Very high(≥ 90)65%
- Confident(70–90)13%
- Low(50–70)18%
- Very low(< 50)4%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
IL6
Chr 7p15.3interleukin 6
- Aliases:
- IL-6, BSF2, HGF, HSF
- MANE:
- ENST00000258743.10
Annotations refreshed 1 month ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
COVID-19 research
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownCerebral vascular malformations
Familial Meniere Disease
Gastrointestinal epithelial barrier disorders
Primary immunodeficiency or monogenic inflammatory bowel disease
UnknownSudden death in young people
Unknown
Disease associations (Open Targets)
asthma
0.56rheumatoid arthritis
0.52immune system disorder
0.51aortic stenosis
0.51atherosclerosis
0.47aortic valve calcification
0.46Giant Lymph Node Hyperplasia
0.46Kaposi sarcoma, susceptibility to
0.46COVID-19
0.44atrial fibrillation
0.43
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Interleukin-6
Cytokine with a wide variety of biological functions in immunity, tissue regeneration, and metabolism. Binds to IL6R, then the complex associates to the signaling subunit IL6ST/gp130 to trigger the intracellular IL6-signaling pathway (Probable). The interaction with the membrane-bound IL6R and IL6ST stimulates 'classic signaling', whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells (Probable)
Diseases associated with IL6
Curated MONDO disease pages that list IL6 among their top associated genes.