AlphaFold predicted structure
IL7R · P16871
Mean pLDDT
67.4/ 100
Low
459 residues
Confidence breakdown
- Very high(≥ 90)40%
- Confident(70–90)8%
- Low(50–70)13%
- Very low(< 50)39%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
IL7R
Chr 5p13.2interleukin 7 receptor
- Aliases:
- CD127, IL7RA, lnc-IL7R, IL-7Ralpha, IL7Ralpha
- MANE:
- ENST00000303115.8
Annotations refreshed 1 month ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
COVID-19 research
BIALLELIC, autosomal or pseudoautosomalPrimary immunodeficiency or monogenic inflammatory bowel disease
BIALLELIC, autosomal or pseudoautosomal
Disease associations (Open Targets)
immunodeficiency 104
0.79asthma
0.59multiple sclerosis
0.58T-B+ severe combined immunodeficiency due to JAK3 deficiency
0.58hypothyroidism
0.57Omenn syndrome
0.56allergic rhinitis
0.55atopic eczema
0.55Eczematoid dermatitis
0.55primary biliary cholangitis
0.55
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Interleukin-7 receptor subunit alpha
Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP)
Diseases associated with IL7R
Curated MONDO disease pages that list IL7R among their top associated genes.