IMPG2

Chr 3q12.3

interphotoreceptor matrix proteoglycan 2

Aliases:: IPM200, RP56, SPACRCAN
MANE:: ENST00000193391.8

OMIM: 607056 ↗NCBI: 50939 ↗Ensembl ↗

Annotations refreshed 1 month ago.

Predicted protein structure

AlphaFold predicted structure

IMPG2 · Q9BZV3

v62025-08-01

Predicted Aligned Error matrix for IMPG2 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

53.6/ 100

Low

1,241 residues

Confidence breakdown

Very high(≥ 90)11%
Confident(70–90)23%
Low(50–70)8%
Very low(< 50)58%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Retinal disorders
BOTH monoallelic and biallelic, autosomal or pseudoautosomal
Glaucoma (developmental)
Structural eye disease
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

retinitis pigmentosa
0.75
retinitis pigmentosa 56
0.71
vitelliform macular dystrophy 5
0.64
Retinal dystrophy
0.57
autosomal recessive retinitis pigmentosa
0.51
adult-onset foveomacular vitelliform dystrophy
0.47
vitelliform macular dystrophy 2
0.47
IMPG2-related recessive retinopathy
0.44
vitelliform macular dystrophy
0.37
Posterior column ataxia - retinitis pigmentosa
0.37

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Interphotoreceptor matrix proteoglycan 2

Chondroitin sulfate- and hyaluronan-binding proteoglycan involved in the organization of interphotoreceptor matrix; may participate in the maturation and maintenance of the light-sensitive photoreceptor outer segment. Binds heparin