AlphaFold predicted structure
INS · P01308
Mean pLDDT
52.9/ 100
Low
110 residues
Confidence breakdown
- Very high(≥ 90)0%
- Confident(70–90)13%
- Low(50–70)36%
- Very low(< 50)51%
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AlphaFold (Jumper et al., 2021) · CC BY 4.0
INS
Chr 11p15.5insulin
- MANE:
- ENST00000381330.5
Annotations refreshed 1 month ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
Diabetes with additional phenotypes suggestive of a monogenic aetiology
BOTH monoallelic and biallelic, autosomal or pseudoautosomalFamilial diabetes
BOTH monoallelic and biallelic, autosomal or pseudoautosomalMonogenic diabetes
BOTH monoallelic and biallelic, autosomal or pseudoautosomalNeonatal diabetes
BOTH monoallelic and biallelic, autosomal or pseudoautosomalMulti-organ autoimmune diabetes
BOTH monoallelic and biallelic, autosomal or pseudoautosomal
Disease associations (Open Targets)
diabetes mellitus, permanent neonatal 4
0.78hyperproinsulinemia
0.74MODY
0.74type 1 diabetes mellitus
0.69permanent neonatal diabetes mellitus
0.68maturity-onset diabetes of the young type 10
0.68diabetes mellitus
0.59monogenic diabetes
0.56type 2 diabetes mellitus
0.52transient neonatal diabetes, dominant/recessive
0.51
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Insulin
Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver
Diseases associated with INS
Curated MONDO disease pages that list INS among their top associated genes.