IPO13

Chr 1p34.1

importin 13

Aliases:: IMP13, KIAA0724, RANBP13
MANE:: ENST00000372343.8

OMIM: 610411 ↗NCBI: 9670 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

IPO13 · O94829

v62025-08-01

Predicted Aligned Error matrix for IPO13 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

90.5/ 100

Very high

963 residues

Confidence breakdown

Very high(≥ 90)80%
Confident(70–90)14%
Low(50–70)3%
Very low(< 50)4%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Structural eye disease
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

Parkinson disease
0.34
lysosomal storage disease
0.34
Alzheimer disease
0.34
neurodegenerative disease
0.34
multiple sclerosis
0.34
Crohn disease
0.09
non-small cell lung carcinoma
0.07
pterygium
0.07
endometrial carcinoma
0.05
neoplasm
0.05

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Importin-13

Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of UBC9, the RBM8A/MAGOH complex, PAX6 and probably other members of the paired homeobox family. Also mediates nuclear export of eIF-1A, and the cytoplasmic release of eIF-1A is triggered by the loading of import substrates onto IPO13