IREB2

Chr 15q25.1

iron responsive element binding protein 2

Aliases:: IRP2
MANE:: ENST00000258886.13

OMIM: 147582 ↗NCBI: 3658 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

IREB2 · P48200

v62025-08-01

Predicted Aligned Error matrix for IREB2 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

86.8/ 100

Confident

963 residues

Confidence breakdown

Very high(≥ 90)66%
Confident(70–90)24%
Low(50–70)3%
Very low(< 50)7%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

DDG2P
BIALLELIC, autosomal or pseudoautosomal
Intellectual disability
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

neurodegeneration, early-onset, with choreoathetoid movements and microcytic anemia
0.67
pneumonia
0.31
chronic obstructive pulmonary disease
0.28
atherosclerosis
0.24
lung disorder
0.23
chronic lung disease
0.22
peripheral vascular disease
0.21
respiratory failure
0.21
chronic bronchitis
0.21
hereditary disease
0.19

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Iron-responsive element-binding protein 2

RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA