IRF2

Chr 4q35.1

interferon regulatory factor 2

MANE:: ENST00000393593.8

OMIM: 147576 ↗NCBI: 3660 ↗Ensembl ↗

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Predicted protein structure

AlphaFold predicted structure

IRF2 · P14316

v62025-08-01

Predicted Aligned Error matrix for IRF2 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

63.9/ 100

Low

349 residues

Confidence breakdown

Very high(≥ 90)30%
Confident(70–90)3%
Low(50–70)30%
Very low(< 50)37%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

COVID-19 research
Unknown

Disease associations (Open Targets)

poisoning
0.30
Alzheimer disease
0.29
Abnormality of the skeletal system
0.28
Parkinson disease
0.27
multiple sclerosis
0.27
neurodegenerative disease
0.27
lysosomal storage disease
0.27
polyarteritis nodosa
0.24
adolescent idiopathic scoliosis
0.24
hidradenitis
0.24

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Interferon regulatory factor 2

DNA-binding transcription factor that specifically binds to the upstream regulatory region of type I interferon (IFN) and IFN-inducible genes and regulates their expression (PubMed:39013473, PubMed:7687740). Mainly acts as a transcription repressor, repressing expression (PubMed:39013473). Also acts as an activator for several genes including H4 and IL7 (PubMed:15226432, PubMed:9540062). Constitutively binds to the ISRE promoter to activate IL7 (PubMed:15226432). Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth (PubMed:9540062). Antagonizes IRF1 transcriptional activation (By similarity)