IRF2BP2

Chr 1q42.3

interferon regulatory factor 2 binding protein 2

Aliases:: LRIR2, IRF-2BP2
MANE:: ENST00000366609.4

OMIM: 615332 ↗NCBI: 359948 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

IRF2BP2 · Q7Z5L9

v62025-08-01

Predicted Aligned Error matrix for IRF2BP2 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

55.8/ 100

Low

587 residues

Confidence breakdown

Very high(≥ 90)18%
Confident(70–90)7%
Low(50–70)12%
Very low(< 50)62%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

COVID-19 research
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Primary immunodeficiency or monogenic inflammatory bowel disease
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Disease associations (Open Targets)

immunodeficiency, common variable, 14
0.64
common variable immunodeficiency
0.47
atrial fibrillation
0.43
mathematical ability
0.40
metabolic disease
0.21
Hypercholesterolemia
0.20
alcohol drinking
0.19
gout
0.19
autoimmune disease
0.17
urolithiasis
0.17

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Interferon regulatory factor 2-binding protein 2

Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities (PubMed:12799427). Represses the NFAT1-dependent transactivation of NFAT-responsive promoters (PubMed:21576369). Acts as a coactivator of VEGFA expression in cardiac and skeletal muscles (PubMed:20702774). Plays a role in immature B-cell differentiation (PubMed:27016798)