interferon regulatory factor 5
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Diagnostic Grade (Green)
COVID-19 research
UnknownGastrointestinal epithelial barrier disorders
systemic lupus erythematosus
rheumatoid arthritis
hypothyroidism
systemic sclerosis
ulcerative colitis
autoimmune disease
inflammatory bowel disease
Sjogren syndrome
clear cell renal carcinoma
papillary renal cell carcinoma
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Interferon regulatory factor 5
Transcription factor that plays a critical role in innate immunity by activating expression of type I interferon (IFN) IFNA and INFB and inflammatory cytokines downstream of endolysosomal toll-like receptors TLR7, TLR8 and TLR9 (PubMed:11303025, PubMed:15695821, PubMed:22412986, PubMed:25326418, PubMed:32433612, PubMed:40639948). Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters (By similarity). Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction downstream of the TLR-activated, MyD88-dependent pathway (By similarity). Key transcription factor regulating the IFN response during SARS-CoV-2 infection (PubMed:33440148)
Curated MONDO disease pages that list IRF5 among their top associated genes.
IRF5 · Q13568
Mean pLDDT
72.6/ 100
Confident
498 residues
Confidence breakdown
AlphaFold (Jumper et al., 2021) · CC BY 4.0
