IRF9

Chr 14q12

interferon regulatory factor 9

MANE:: ENST00000396864.8

OMIM: 147574 ↗NCBI: 10379 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

IRF9 · Q00978

v62025-08-01

Predicted Aligned Error matrix for IRF9 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

74.6/ 100

Confident

393 residues

Confidence breakdown

Very high(≥ 90)41%
Confident(70–90)25%
Low(50–70)10%
Very low(< 50)24%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

COVID-19 research
BIALLELIC, autosomal or pseudoautosomal
Primary immunodeficiency or monogenic inflammatory bowel disease
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

immunodeficiency 65, susceptibility to viral infections
0.50
neoplasm
0.11
nonpapillary renal cell carcinoma
0.09
rheumatoid arthritis
0.09
pulmonary arterial hypertension
0.09
lung cancer
0.08
lung carcinoma
0.08
acute promyelocytic leukemia
0.08
acute myeloid leukemia
0.07
cancer
0.07

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Interferon regulatory factor 9

Transcription factor that plays an essential role in anti-viral immunity. It mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. IRF9/ISGF3G associates with the phosphorylated STAT1:STAT2 dimer to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state