ITGA2B

Chr 17q21.31

integrin subunit alpha 2b

Aliases:: CD41B, CD41, PPP1R93, GPIIb
MANE:: ENST00000262407.6

OMIM: 607759 ↗NCBI: 3674 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

ITGA2B · P08514

v62025-08-01

Predicted Aligned Error matrix for ITGA2B — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

88.1/ 100

Confident

1,039 residues

Confidence breakdown

Very high(≥ 90)71%
Confident(70–90)18%
Low(50–70)3%
Very low(< 50)7%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Bleeding and platelet disorders
BOTH monoallelic and biallelic, autosomal or pseudoautosomal
Inherited bleeding disorders
BOTH monoallelic and biallelic, autosomal or pseudoautosomal
Cytopenia - NOT Fanconi anaemia
BIALLELIC, autosomal or pseudoautosomal
Cytopenias and congenital anaemias

Disease associations (Open Targets)

Glanzmann thrombasthenia 1
0.84
Glanzmann thrombasthenia
0.75
autosomal dominant macrothrombocytopenia
0.69
cancer
0.60
myocardial infarction
0.57
acute coronary syndrome
0.54
Noonan syndrome
0.53
hypertrophic cardiomyopathy
0.51
Costello syndrome
0.50
Recurrent thrombophlebitis
0.50

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Integrin alpha-IIb

Integrin alpha-IIb/beta-3 (ITGA2B:ITGB3) is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain (By similarity). Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen (PubMed:9111081). This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface (By similarity). Integrin ITGA2B:ITGB3 is also the receptor of erythrocyte-specific ICAM4 ligand involved in heterotypic cell-cell adhesion between erythrocytes and activated platelets (PubMed:12477717)