ITGA6

Chr 2q31.1

integrin subunit alpha 6

Aliases:: CD49f, VLA-6, ITGA6A, ITGA6B
MANE:: ENST00000684293.1

OMIM: 147556 ↗NCBI: 3655 ↗Ensembl ↗

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Predicted protein structure

AlphaFold predicted structure

ITGA6 · P23229

v62025-08-01

Predicted Aligned Error matrix for ITGA6 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

80.4/ 100

Confident

1,130 residues

Confidence breakdown

Very high(≥ 90)43%
Confident(70–90)37%
Low(50–70)8%
Very low(< 50)12%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Epidermolysis bullosa
BIALLELIC, autosomal or pseudoautosomal
Epidermolysis bullosa and congenital skin fragility
BIALLELIC, autosomal or pseudoautosomal
Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal
DDG2P
BIALLELIC, autosomal or pseudoautosomal
Ectodermal dysplasia
BIALLELIC, autosomal or pseudoautosomal
Familial cicatricial alopecia
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

junctional epidermolysis bullosa with pyloric atresia
0.70
Junctional epidermolysis bullosa - pyloric atresia
0.67
epidermolysis bullosa, junctional 6, with pyloric atresia
0.62
prostate carcinoma
0.51
prostate cancer
0.45
Varicose veins
0.40
alcohol drinking
0.38
generalized junctional epidermolysis bullosa non-Herlitz type
0.37
junctional epidermolysis bullosa
0.34
vein disorder
0.33

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Integrin alpha-6

Integrin alpha-6/beta-1 (ITGA6:ITGB1) is a receptor for laminin on platelets (By similarity). Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion (By similarity). Integrin alpha-6/beta-4 (ITGA6:ITGB4) is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome (By similarity). ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760). ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464)