ITPKB

Chr 1q42.12

inositol-trisphosphate 3-kinase B

Aliases:: IP3KB, IP3-3KB
MANE:: ENST00000429204.6

OMIM: 147522 ↗NCBI: 3707 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

ITPKB · P27987

v62025-08-01

Predicted Aligned Error matrix for ITPKB — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

55.3/ 100

Low

946 residues

Confidence breakdown

Very high(≥ 90)23%
Confident(70–90)9%
Low(50–70)4%
Very low(< 50)64%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

COVID-19 research
BIALLELIC, autosomal or pseudoautosomal
Primary immunodeficiency or monogenic inflammatory bowel disease
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

Parkinson disease
0.58
neurodegenerative disease
0.54
asthma
0.43
myeloproliferative neoplasm, unclassifiable
0.42
respiratory system disorder
0.41
allergic disease
0.37
Abnormality of refraction
0.34
Alzheimer disease
0.32
multiple sclerosis
0.31
lysosomal storage disease
0.31

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Inositol-trisphosphate 3-kinase B

Catalyzes the phosphorylation of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) into 1D-myo-inositol 1,3,4,5-tetrakisphosphate and participates to the regulation of calcium homeostasis