ITPKC

Chr 19q13.2

inositol-trisphosphate 3-kinase C

Aliases:: IP3KC, IP3-3KC
MANE:: ENST00000263370.3

OMIM: 606476 ↗NCBI: 80271 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

ITPKC · Q96DU7

v62025-08-01

Predicted Aligned Error matrix for ITPKC — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

58.9/ 100

Low

683 residues

Confidence breakdown

Very high(≥ 90)32%
Confident(70–90)6%
Low(50–70)2%
Very low(< 50)59%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

COVID-19 research
Unknown

Disease associations (Open Targets)

Kawasaki disease
0.40
neurodegenerative disease
0.35
autoimmune disorder of central nervous system
0.24
inflammatory bowel disease
0.13
breast carcinoma
0.05
breast cancer
0.04
neoplasm
0.04
cancer
0.03
dementia
0.03
Erythema
0.02

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Inositol-trisphosphate 3-kinase C

Catalyzes the phosphorylation of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) into 1D-myo-inositol 1,3,4,5-tetrakisphosphate and participates to the regulation of calcium homeostasis (PubMed:11085927, PubMed:12747803). Can phosphorylate inositol 2,4,5-triphosphate to inositol 2,4,5,6-tetraphosphate (By similarity)