IVNS1ABP

Chr 1q25.3

influenza virus NS1A binding protein

Aliases:: NS1-BP, HSPC068, NS-1, KIAA0850, ND1
MANE:: ENST00000367498.8

OMIM: 609209 ↗NCBI: 10625 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

IVNS1ABP · Q9Y6Y0

v62025-08-01

Predicted Aligned Error matrix for IVNS1ABP — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

84.7/ 100

Confident

642 residues

Confidence breakdown

Very high(≥ 90)67%
Confident(70–90)16%
Low(50–70)5%
Very low(< 50)12%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

COVID-19 research
Unknown
Primary immunodeficiency or monogenic inflammatory bowel disease
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Disease associations (Open Targets)

immunodeficiency 70
0.53
neurodegenerative disease
0.42
placental retention
0.31
nervous system benign neoplasm
0.24
response to antihypertensive drug
0.22
late-onset Alzheimers disease
0.21
dislocation
0.21
vertebral column disorder
0.20
femur fracture
0.18
chronic kidney disease
0.17

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Influenza virus NS1A-binding protein

Involved in many cell functions, including pre-mRNA splicing, the aryl hydrocarbon receptor (AHR) pathway, F-actin organization and protein ubiquitination. Plays a role in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats (By similarity). Protects cells from cell death induced by actin destabilization (By similarity). Functions as modifier of the AHR/Aryl hydrocarbon receptor pathway increasing the concentration of AHR available to activate transcription (PubMed:16582008). In addition, functions as a negative regulator of BCR(KLHL20) E3 ubiquitin ligase complex to prevent ubiquitin-mediated proteolysis of PML and DAPK1, two tumor suppressors (PubMed:25619834). Inhibits pre-mRNA splicing (in vitro) (PubMed:9696811). May play a role in mRNA nuclear export (PubMed:30538201)