IYD

Chr 6q25.1

iodotyrosine deiodinase

Aliases:: dJ422F24.1, DEHAL1
MANE:: ENST00000344419.8

OMIM: 612025 ↗NCBI: 389434 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

IYD · Q6PHW0

v62025-08-01

Predicted Aligned Error matrix for IYD — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

88.1/ 100

Confident

289 residues

Confidence breakdown

Very high(≥ 90)69%
Confident(70–90)16%
Low(50–70)9%
Very low(< 50)6%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Congenital hypothyroidism
BOTH monoallelic and biallelic, autosomal or pseudoautosomal

Disease associations (Open Targets)

familial thyroid dyshormonogenesis
0.65
respiratory system disorder
0.31
iron metabolism disease
0.10
rectosigmoid junction neoplasm
0.09
Barrett esophagus
0.07
hepatitis B virus infection
0.07
esophageal adenocarcinoma
0.04
hepatocellular carcinoma
0.04
clear cell renal carcinoma
0.04
hypothyroidism
0.03

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Iodotyrosine deiodinase 1

Catalyzes the dehalogenation of halotyrosines such as 3-bromo-L-tyrosine, 3-chloro-L-tyrosine, 3-iodo-L-tyrosine and 3,5-diiodo-L-tyrosine (PubMed:15289438, PubMed:18434651, PubMed:25395621, PubMed:28157283). During thyroid hormone biosynthesis, facilitates iodide salvage by catalysing the oxidative NADPH-dependent deiodination of the halogenated by-products of thyroid hormone production, monoiodotyrosine (L-MIT) and diiodotyrosine (L-DIT) (PubMed:15289438, PubMed:18434651). The scavanged iodide can then reenter the hormone-producing pathways (PubMed:15289438, PubMed:18434651). Acts more efficiently on 3-iodo-L-tyrosine than 3,5-diiodo-L-tyrosine (PubMed:15289438)