AlphaFold predicted structure
JAM3 · Q9BX67
Mean pLDDT
85.1/ 100
Confident
310 residues
Confidence breakdown
- Very high(≥ 90)72%
- Confident(70–90)6%
- Low(50–70)9%
- Very low(< 50)13%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
JAM3
Chr 11q25junctional adhesion molecule 3
- Aliases:
- JAM-C, JAMC, JAM-3
- MANE:
- ENST00000299106.9
Annotations refreshed 10 hours ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
Bilateral congenital or childhood onset cataracts
BIALLELIC, autosomal or pseudoautosomalDDG2P
BIALLELIC, autosomal or pseudoautosomalFetal anomalies
BIALLELIC, autosomal or pseudoautosomalIntellectual disability
BIALLELIC, autosomal or pseudoautosomalIntracerebral calcification disorders
BIALLELIC, autosomal or pseudoautosomalWhite matter disorders and cerebral calcification - narrow panel
BIALLELIC, autosomal or pseudoautosomalInherited white matter disorders
Structural eye disease
BIALLELIC, autosomal or pseudoautosomal
Disease associations (Open Targets)
porencephaly-microcephaly-bilateral congenital cataract syndrome
0.79atrial fibrillation
0.35stroke disorder
0.26alcohol drinking
0.26nephrotic syndrome
0.25temporomandibular joint disorder
0.25blood vessel replacement
0.24bronchial disorder
0.24corneal dystrophy
0.24hereditary disease
0.19
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Junctional adhesion molecule C
Junctional adhesion protein that mediates heterotypic cell-cell interactions with its cognate receptor JAM2 to regulate different cellular processes (PubMed:11590146, PubMed:11823489). Plays a role in homing and mobilization of hematopoietic stem and progenitor cells within the bone marrow. At the surface of bone marrow stromal cells, it contributes to the retention of the hematopoietic stem and progenitor cells expressing JAM3 (PubMed:11590146, PubMed:24357068). Plays a central role in leukocytes extravasation by facilitating transmigration through the endothelium (By similarity). Plays a role in spermatogenesis where JAM2 and JAM3, which are respectively expressed by Sertoli and germ cells, mediate an interaction between both cell types and play an essential role in the anchorage of germ cells onto Sertoli cells and the assembly of cell polarity complexes during spermatid differentiation (By similarity). Also functions as a counter-receptor for ITGAM, mediating leukocyte-platelet interactions and is involved in the regulation of transepithelial migration of polymorphonuclear neutrophils (PMN) (PubMed:12208882, PubMed:15194813). Plays a role in angiogenesis (PubMed:23255084). Plays a role in the regulation of cell migration (Probable). During myogenesis, it is involved in myocyte fusion (By similarity)