KCNA3

Chr 1p13.3

potassium voltage-gated channel subfamily A member 3

Aliases:: Kv1.3, MK3, HLK3, HPCN3, RP11-284N8.3
MANE:: ENST00000369769.4

OMIM: 176263 ↗NCBI: 3738 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

KCNA3 · P22001

v62025-08-01

Predicted Aligned Error matrix for KCNA3 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

72.0/ 100

Confident

575 residues

Confidence breakdown

Very high(≥ 90)50%
Confident(70–90)10%
Low(50–70)6%
Very low(< 50)34%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Early onset or syndromic epilepsy
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Intellectual disability
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Disease associations (Open Targets)

multiple sclerosis
0.60
Lambert-Eaton myasthenic syndrome
0.56
myasthenia gravis
0.56
neurodevelopmental disorder
0.53
congenital myasthenic syndrome
0.49
Congenital myasthenic syndromes
0.49
Muscle weakness
0.46
neoplasm
0.39
epilepsy
0.39
cancer
0.39

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Potassium voltage-gated channel subfamily A member 3

Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient