KCNN3

Chr 1q21.3

potassium calcium-activated channel subfamily N member 3

Aliases:: KCa2.3, hSK3, SKCA3
MANE:: ENST00000271915.9

OMIM: 602983 ↗NCBI: 3782 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

KCNN3 · Q9UGI6

v62025-08-01

Predicted Aligned Error matrix for KCNN3 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

67.8/ 100

Low

731 residues

Confidence breakdown

Very high(≥ 90)35%
Confident(70–90)23%
Low(50–70)1%
Very low(< 50)41%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

DDG2P
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Intellectual disability
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Limb disorders
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Fetal anomalies
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Ductal plate malformation
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Disease associations (Open Targets)

Zimmermann-Laband syndrome 3
0.68
Zimmermann-Laband syndrome
0.67
atrial fibrillation
0.37
hereditary disease
0.34
atrial flutter
0.33
cardiac arrhythmia
0.31
heart disorder
0.28
alcohol drinking
0.27
chronic obstructive pulmonary disease
0.26
prostate carcinoma
0.21

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Small conductance calcium-activated potassium channel protein 3

Small conductance calcium-activated potassium channel that mediates the voltage-independent transmembrane transfer of potassium across the cell membrane through a constitutive interaction with calmodulin which binds the intracellular calcium allowing its opening (PubMed:12808432, PubMed:20562108, PubMed:31155282, PubMed:36502918). The current is characterized by a voltage-independent activation, an intracellular calcium concentration increase-dependent activation and a single-channel conductance of 10 picosiemens (PubMed:12808432, PubMed:20562108, PubMed:31155282, PubMed:36502918). Also presents an inwardly rectifying current, thus reducing its already small outward conductance of potassium ions, which is particularly the case when the membrane potential displays positive values, above + 20 mV (PubMed:12808432). Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization (By similarity)