KCNT1

Chr 9q34.3

potassium sodium-activated channel subfamily T member 1

Aliases:: KCa4.1, KIAA1422, SLACK, Slo2.2
MANE:: ENST00000371757.7

OMIM: 608167 ↗NCBI: 57582 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

KCNT1 · Q5JUK3

v62025-08-01

Predicted Aligned Error matrix for KCNT1 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

73.9/ 100

Confident

1,230 residues

Confidence breakdown

Very high(≥ 90)36%
Confident(70–90)34%
Low(50–70)6%
Very low(< 50)24%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

DDG2P
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Early onset or syndromic epilepsy
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Intellectual disability
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Fetal anomalies
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Disease associations (Open Targets)

developmental and epileptic encephalopathy, 14
0.81
autosomal dominant nocturnal frontal lobe epilepsy 5
0.78
autosomal dominant nocturnal frontal lobe epilepsy
0.59
malignant migrating partial seizures of infancy
0.58
Seizure
0.51
hereditary disease
0.51
epilepsy
0.47
childhood-onset epilepsy syndrome
0.45
sleep-related hypermotor epilepsy
0.39
familial sleep-related hypermotor epilepsy
0.39

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Potassium channel subfamily T member 1

Sodium-activated K(+) channel (PubMed:37494189). Acts as an important mediator of neuronal membrane excitability (PubMed:37494189). Contributes to the delayed outward currents (By similarity). Regulates neuronal bursting in sensory neurons (By similarity). Contributes to synaptic development and plasticity (By similarity)