KCNT2

Chr 1q31.3

potassium sodium-activated channel subfamily T member 2

Aliases:: KCa4.2, SLICK, SLO2.1
MANE:: ENST00000294725.14

OMIM: 610044 ↗NCBI: 343450 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

KCNT2 · Q6UVM3

v62025-08-01

Predicted Aligned Error matrix for KCNT2 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

76.1/ 100

Confident

1,135 residues

Confidence breakdown

Very high(≥ 90)35%
Confident(70–90)40%
Low(50–70)4%
Very low(< 50)20%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Early onset or syndromic epilepsy
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Intellectual disability
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
DDG2P
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Disease associations (Open Targets)

genetic developmental and epileptic encephalopathy
0.67
age-related macular degeneration
0.41
Seizure
0.41
macular degeneration
0.41
degeneration of macula and posterior pole
0.38
retinal disorder
0.34
acquired thrombocytopenia
0.32
wet macular degeneration
0.31
disorder of visual system
0.29
kidney transplant
0.29

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Potassium channel subfamily T member 2

Sodium-activated and chloride-activated potassium channel (PubMed:14684870, PubMed:16687497, PubMed:25214519, PubMed:27682982, PubMed:29069600, PubMed:29740868). Produces rapidly activating outward rectifier K(+) currents (PubMed:14684870). Contributes to regulate neuronal excitability (PubMed:29069600)